Growth and yield response of rodent tuber typhonium. These were murashige and skoog ms, nitsch and nitsch nn, gamborg b5 gb5 and white w of which ms medium was found to be the best medium for in vitro culture of t. Antibacterial and antioxidant activity of keladi tikus leaves. Characterisation of two photosensitizing compounds from. Cytotoxic activity of typhonium flagelliforme araceae. Keladi tikus typhonium flagelliforme lodd blume is a plant that has many benefits in health such as anticancer, antiinflammatory, analgesic and. This page was last edited on 8 december 2019, at 15. Two putative photosensitizers, pbeophorbidea and a possible novel derivative, 2, 17dihydroxyethyl pheophorhidea were isolated using column chromatography and purified on thin layer. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs alternatively, you can download the pdf file directly to your computer, from where it. Bap is a cytokinintype pgr that is effective in inducing the production and propagation of buds from bud eyes gunawan, 1987. In vitro culture plants of typhonium flagelliforme were found to decolorize a variety of dyes, including malachite green, red he 8b, methyl. Pdf anticancerous effect of typhonium flagelliforme on. Typhonium flagelliforme rodent tuber is a herbal plant which grows up to 30cm in height. How typhonium giganteum is effective for various diseases is listed in repertory format.
Rodent tuber, keladi tikus, tu ban xia or lao shu yu botanical name. Files are available under licenses specified on their description page. Edp 50 values of the hexane fractions of the mature plant and thein vitro plantlet oft. Names of typhonium giganteum in various languages of the world are also given. Typhonium flagelliforme inhibits the proliferation of. The agar diffusion method used in the antibacterial activity. A bioassay guided approach was used to isolate photosensitizing compounds from typhonium flagelliforme schott, a plant considered by local communities to possess anticancer properties. Chemical ingredients were identified as methyl esters of hexadecanoic acid, octadecanoic acid, 9octadecenoic acid and 9,12 octadecadienoic acid. Antileukemic effects of typhonium flagelliforme on human.
Anin vitro cytotoxicity screening of thetyphonium flagelliforme extracts indicated high cytotoxicity effect on human lung carcinoma nclh23 cells and human mammary gland carcinoma t47d cells, but the extracts were not active on human liver carcinoma hepg2 cells. The plant typhonium flagelliforme tf, commonly known as rodent tuber in malaysia, is often used as traditional. Typhonium plus contains ribosome in acting protein rip, anti oxidant, and anti curcumin. Typhonium flagelliforme inhibits cancer cell growth in vitro and induces apoptosis an evaluation. Typhonium flagelliforme is a species of flowering plant in the family araceae typhonium flagelliforme is native to guangdong, guangxi, yunnan, bangladesh, bhutan. Nowadays, the treatment of tumors using a traditional way, including the use of herbal substances, becomes popular. Typhonium flagelliforme induces apoptosis in cemss cells via activation of caspase9, parp cleavage and cytochrome c release.
Two putative photosensitizers, pbeophorbidea and a possible novel derivative, 2, 17dihydroxyethyl pheophorhidea were isolated using column chromatography. In vitro anticancer activity was assayed by mtt method on widr colon cancer cells. Keladi tikus typhonium flagelliforme lodd blume is a plant that has many benefits in health such as anticancer, antiinflammatory, analgesic and antihepatotoxic. This plant had shown to induce antiproliferative effect. Typhonium flagelliforme, previously mistakenly referred as typhonium divaricatum nicolson and sivadasan, 1981, is commonly known as rodent tuber in malaysia. Homeopathy is a very unique system of medicine because the ingredients are used at levels generally understood to be nontoxic, with no negative side effects. Based on the result of gcms, in the nbutanol extract of typhonium flagelliforme lodd. Cytotoxicity effects of typhonium flagelliforme and clinacanthus nutans on breast cancer cells. Here, we investigated in vitro and in vivo effects. Typhonium flagelliforme inhibits cancer cell growth in vitro. Download fulltext pdf download fulltext pdf antibacterial and antioxidant activity of keladi tikus leaves extract typhonium flagelliforme lodd blume article pdf available december 2014. Typhonium plus complementary alternative cancer treatment.
Introduction typhonium flagelliforme is a medicinal herb which belongs to the araceae arum family. All structured data from the file and property namespaces is available under the creative commons cc0 license. Typhonium flagelliforme is a species of flowering plant in the family araceae. Typhonium giganteum herb uses, benefits, cures, side effects. In vitro propagation of typhonium flagelliforme lodd blume. Rodent tuber grows wild in wasteland and is native to the south east asian countries. Natural products always offer alternate treatment therapies that are safe and effective. Keladi tikus rodent tuber typhonium flagelliforme lood bl. Rodent tuber keladi tikus obat kanker pengobatan kanker. A cerebroside, with significant antihepatotoxic activity and phenylpropanoid glycosides isolated from flagelliforme typhyonium for the first time huang et al.
Its activation coupled with g0g1 phase cell cycle arrest. These are primarily included because names of species rank are. Antibacterial and antioxidant activity of keladi tikus leaves extract. Typhonium flagelliforme extract and other herbs combine help in the detoxification of the blood system. Blume is guess contains flavonoid compounds as dihidroflavonol groups, flavon, isoflavon and auron key words. The plant list includes a further 14 scientific plant names of infraspecific rank for the genus typhonium. Abstractobjectiveto determine the inhibition activity of typhonium flagelliforme lodd.
Typhonium flagelliforme have been reported to act as. Micropropagation of rodent tuber typhonium flagelliforme lodd. This study aims to determine the antibacterial and antioxidant activity of different extracts of leaves t. Typhonium flagelliforme antiproliferation activity, while interferons ifns one of the cytokines that first used as an antiviral agent was also known to have antitumor activity. The hexane extract from typhonium flagelliforme tuber had interesting activity against both the gram negative.
Typhonium flagelliforme induces apoptosis in cemss cells. Rodent tuber typhonium flagelliforme lodd blume is one of the medicinal plants used for anticancer treatment, but the information on the cultivation of the plant is limited. Blume, commonly known as rodent tuber in malaysia, is one of the widely used alternative medicines in cancer therapy by south east asian population. To determine the inhibition activity of typhonium flagelliforme lodd. K ras is an oncogenic gtpase responsible for at least 1525% of all nonsmall cell lung cancer cases worldwide. The plant list includes 115 scientific plant names of species rank for the genus typhonium. This page was last edited on 16 december 2019, at 17. Typhonium flagelliforme, phytochemicals, traditional medicine. This plant grows wild in wasteland and is native to the south east asian countries. Being described ethnomedically as toxic, warming and phlegm resolving, this plant is used to soothe swelling, coughing and more predominantly for the treatment of cancer teo and ch. Pdf typhonium flagelliforme inhibits cancer cell growth.
Pdf typhonium flagelliforme inhibits cancer cell growth in. It is now grown in many malaysian and s ingaporean household gardens for its medicinal value. One to five small blue green leaves appear flat against the ground following flowering. Typhonium flagelliforme or keladi tikus is a local plant known to. Typhonium flagelliforme inhibits cancer cell growth in. The effects of gamma irradiation on growth response of rodent. Pdf antibacterial and antioxidant activities of typhonium. Typhonium flagelliforme tf is a tropical plant, traditionally used by the ethnic population of malaysia for the cure of various cancers. These supplement products were developed from research indicating that ephedrine, a naturallyoccurring compound mainly found in species of ephedra, behaves much like the drugs amphetamine and dexamphetamine dexedrine, used to stimulate energy, reduce.
Blume araceae is a malaysian plant used locally to combat cancer. Typhonium flagelliforme is a species of flowering plant in the family araceae typhonium flagelliforme is native to guangdong, guangxi, yunnan, bangladesh, bhutan, cambodia, india, indonesia, laos, malaysia, myanmar, philippines, singapore, sri lanka, thailand, new guinea, queensland, and the australian northern territory references. It has an oblong whitish tuber, triangular leaves ad a spathe. To date, there has been no literature reported on the mechanism of typhonium flagelliforme and its effects on leukemia. In silico screening of mutated kras inhibitors from. The hexane extract was reported to contain saturated hydrocarbons and aliphatic acids 7, while the ethyl. All varieties of this plant produced a single inflorescence consisting of a spadix, surrounded by. The objectives of this research was to study the effect of light intensity and concentration level. Typhonium flagelliforme from the fam ily araceae is locally known as rodent tuber. Typhonium flagelliforme is native to guangdong, guangxi, yunnan, bangladesh. Typhonium giganteum herb uses, benefits, cures, side.
Typhonium flagelliforme inhibits the proliferation of murine. Reports about adverse effects from dietary supplements for weight loss that contain ephedrine have been appearing for more than a decade. Typhonium flagelliforme is currently being investigated for its cancer curing properties and has long been used as a traditional medicine in parts of asia. Typhonium divaricatum is a green plant about one foot tall. Pdf typhonium flagelliforme is a prominent plant candidate from aroid family. The plant typhonium flagelliforme, commonly known as rodent tuber in malaysia, is often used as a health supplement and traditional remedy. Extraction and fractionation using organic solvents were applied to obtain fractions from t. Pdf antibacterial and antioxidant activity of keladi.
Intake of this plant is common among patients with malignancies. Gamma irradiation can be used to increase genetic variation. The pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader if you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs. In order to evaluate its antiproliferative activity in vitro and to possibly identify the active chemical constituents, a bioactivity guided study was conducted on the extracts of this plant. Together triggered cells may in turn produce mediators that stimulate and strengthen other cells of the immune system of the body to combat the. In vitro culture plants of typhonium flagelliforme were found to decolorize a variety of dyes, including malachite green, red he 8b, methyl orange, reactive red 2, direct red 5b dr5b, red he 7b, golden yellow her, patent blue, and brilliant blue r bbr, to varying extents within 4 days. Conventional treatments have been used to treat cancer. Antiproliferation activity of tuber protein from typhonium flagelliforme lodd. An in vitro culture system was developed for typhonium flagelliforme using buds from the rhizomes. The effects of gamma irradiation on growth response of. Its flower ends in a long filament resembling the tail of a mouse, hence its popular lay name. The major aim of this study was to investigate the effect of typhonium flagelliforme crude extract on hepatocarcinogenesis in rats induced by. Blume araceae is a herbal plant which grows up to 30cm in height. Various extracts prepared from either the roots, tubers, stems or leaves were tested for cytotoxic activity on murine p388 leukaemia cells using the mtt assay method.
The board of trustees of the royal botanic gardens, kew. Even though the potential use of bioactive compounds from t. Typhonium flagelliforme induces apoptosis in cemss cells via. Pages in category typhonium the following 4 pages are in this category, out of 4 total. List of various diseases cured by typhonium giganteum. Antibacterial and antioxidant activity of keladi tikus. Typhonium praetermissum is a perennial herb with aerial parts emerging annually from a bulbous corm. Typhonium flagelliforme is an indigenous plant of malaysia and is. This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells. Staminodes variable, spatulate to filamentous or variously reduced. Typhonium flagelliforme in world checklist of selected plant families.
Ingredients typhonium plus alternative cancer treatment. Lung cancer of both types is increasing with an alarming rate due to smoking habits in malaysia among men and women. Leaf shape varies from simple elliptic to deeply divided, with blade length to 4. Studies on phytoremediation potentiality of typhonium flagelliforme.
In vitro propagation of typhonium flagelliforme lodd. Female flowers 1loculed with 1 or 2or 3 orthotropous basal ovules. Fraction from typhonium flagelliforme tuber citeseerx. Analysis of preliminary phytochemical screening of typhonium. Pdf antibacterial and antioxidant activity of keladi tikus. The plant typhonium flagelliforme araceae, commonly known as the rodent tuber, is often included as an essential ingredient in various herbal remedies recommended for cancer therapies in malaysia. Oct 30, 2018 typhonium flagelliforme in world checklist of selected plant families.
Cytotoxic effect, assessed with mtt assays, measured the absorbance of formazan complex at 595 nm that equaled to the. Isolation and identification nbutanol extract from keladi. However, there is no available information to address that tf affects murine leukemia cells in vitro and in vivo. Celecoxib, a selective cox2 inhibitor, was used as a positive control. Typhonium flagelliforme is a medicinal herb which belongs to the araceae arum family. The plant typhonium flagelliforme tf, commonly known as rodent tuber in malaysia, is often used as traditional remedy for cancer, including. Typhonium flagelliforme or keladi tikus is a local. Uses, benefits, cures, side effects, nutrients in typhonium giganteum. The enzymatic analysis of plant roots of aseptically raised plantlets performed before and after. Dries damp, transforms phlegm, expels wind, and stops spasms for windstroke conditions, tremors, convulsions, facial paralysis, hemiplegia, bells palsy, epilepsy, tetanus, and migraines eliminates toxicity and dissipates toxicity for scrofula, snake bites, and other nodules due to phlegm and toxicity. It is being used traditionally in malaysia to treat cancer.
Jan 01, 2001 the plant typhonium flagelliforme araceae, commonly known as the rodent tuber, is often included as an essential ingredient in various herbal remedies recommended for cancer therapies in malaysia. We do not intend the plant list to be complete for names of infraspecific rank. Analysis of preliminary phytochemical screening of. Pdf cytotoxicity effects of typhonium flagelliforme and. About typhonium typhonium plus alternative cancer treatment. Typhonium flagelliforme inhibits the proliferation of murine leukemia wehi3 cells in vitro and induces apoptosis in vivo abstract typhonium flagelliforme tf is a tropical plant, traditionally used by the ethnic population of malaysia for the cure of various cancers. However, these treatments produced inefficient effects and low survival. Studies on phytoremediation potentiality of typhonium. Nevertheless, it is a rarely seen plant in cultivation and not often seen in collections. Pdf antiproliferation activity of tuber protein from. Hence, the antileukemia effect of typhonium flagelliforme was investigated in vitro and in vivo leukemic model.
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